Core Video. Predictive Permeation is also known as DEP or Dermoelectroporation. It is an FDA cleared device that allows the placement of micro and macromolecules up to 3 million Daltons under the skin without the use of needles. It works by rapid polarity changes that then open the water channels of the skin. The technology can be used to place products under the skin such as numbing cream for pre op use, PRP, Amniotic Fluid, Exosomes, Collagen, Hyaluronic Acid, Vitamin C, Retin A, Hydroquinone, Botox.